Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors-Reference-Cited by-同舟云学术

Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors

Published:2018-08-10 Issue:6402 Volume:361 Page:594-599
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Young Matthew D.¹^ORCID,Mitchell Thomas J.¹²³^ORCID,Vieira Braga Felipe A.¹^ORCID,Tran Maxine G. B.⁴⁵^ORCID,Stewart Benjamin J.⁶^ORCID,Ferdinand John R.⁶^ORCID,Collord Grace¹²⁷^ORCID,Botting Rachel A.⁸,Popescu Dorin-Mirel⁸,Loudon Kevin W.⁶,Vento-Tormo Roser¹,Stephenson Emily⁸^ORCID,Cagan Alex¹,Farndon Sarah J.¹⁹¹⁰^ORCID,Del Castillo Velasco-Herrera Martin¹^ORCID,Guzzo Charlotte¹^ORCID,Richoz Nathan⁶,Mamanova Lira¹^ORCID,Aho Tevita²,Armitage James N.³,Riddick Antony C. P.³,Mushtaq Imran⁹,Farrell Stephen²,Rampling Dyanne⁹,Nicholson James²⁷,Filby Andrew⁸,Burge Johanna²,Lisgo Steven¹¹^ORCID,Maxwell Patrick H.¹²,Lindsay Susan¹¹^ORCID,Warren Anne Y.²^ORCID,Stewart Grant D.²³^ORCID,Sebire Neil⁹¹⁰,Coleman Nicholas²¹³,Haniffa Muzlifah⁸¹⁴^ORCID,Teichmann Sarah A.¹^ORCID,Clatworthy Menna²⁶^ORCID,Behjati Sam¹²⁷^ORCID

Affiliation:

1. Wellcome Sanger Institute, Hinxton CB10 1SA, UK.

2. Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.

3. Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK.

4. UCL Division of Surgery and Interventional Science, Royal Free Hospital, London NW3 2PS, UK.

5. Specialist Centre for Kidney Cancer, Royal Free Hospital, London NW3 2PS, UK.

6. Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QQ, UK.

7. Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK.

8. Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

9. Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.

10. UCL Great Ormond Street Hospital Institute of Child Health, London WC1N 1E, UK.

11. Human Developmental Biology Resource, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK.

12. Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK.

13. Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK.

14. Department of Dermatology, Royal Victoria Infirmary, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK.

Abstract

Pediatric and adult kidney tumors differ Understanding tumor origins and the similarities and differences between organ-specific cancers is important for determining treatment options. Young et al. generated more than 72,000 single-cell transcriptomes from healthy and cancerous human kidneys. From these data, they determined that Wilms tumor, a pediatric kidney cancer, originates from aberrant fetal cells, whereas adult kidney cancers are likely derived from a specific subtype of proximal convoluted tubular cell. Science , this issue p. 594

Funder

Human Frontier Science Program

Wellcome Trust

Cancer Research UK

Cambridge Biomedical Research Campus

Kidney Cancer UK

Facing up 2 Kidney Cancer

St Baldrick’s Foundation

Lister Institute of Preventive Medicine

NIHR and Newcastle-Biomedical Research Centre

Arthritis Research UK

EMBO