SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism-Reference-Cited by-同舟云学术

SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism

Published:2018-11-16 Issue:6416 Volume:362 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kory Nora¹²³⁴^ORCID,Wyant Gregory A.¹²³⁴^ORCID,Prakash Gyan¹^ORCID,uit de Bos Jelmi¹^ORCID,Bottanelli Francesca⁵,Pacold Michael E.¹²³⁴⁶^ORCID,Chan Sze Ham¹^ORCID,Lewis Caroline A.¹^ORCID,Wang Tim¹²³⁴,Keys Heather R.¹^ORCID,Guo Yang Eric¹,Sabatini David M.¹²³⁴^ORCID

Affiliation:

1. Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.

2. Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

3. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Department of Biology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

4. Broad Institute of Harvard and Massachusetts Institute of Technology, 415 Main Street, Cambridge, MA 02142, USA.

5. Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA.

6. Department of Radiation Oncology at NYU Langone Medical Center, New York, NY 10016, USA.

Abstract

Mitochondrial serine transporter identified One-carbon (1C) metabolism is a universal metabolic process that is required for purine synthesis and supports the high levels of proliferation in cancer cells. The transport of serine into mitochondria supplies most of the 1C units needed for biosynthesis. Kory et al. used a genetic screen to identify the long-sought-after mitochondrial serine transporter. Elucidating the key step of serine transport is important for our understanding of metabolism and has potential implications for cancer treatment. Science , this issue p. eaat9528

Funder

National Institutes of Health

U.S. Department of Defense

Howard Hughes Medical Institute

Damon Runyon Cancer Research Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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