Serine and one-carbon metabolism in cancer
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Earth and Planetary Sciences,General Environmental Science
Link
http://www.nature.com/articles/nrc.2016.81.pdf
Reference132 articles.
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3. Maddocks, O. D. et al. Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature 493, 542–546 (2013). This paper describes how the tumour suppressor p53 helps cells to adapt to serine starvation, and a therapeutic benefit of dietary depletion of serine in a mouse xenograft model.
4. Kalhan, S. C. & Hanson, R. W. Resurgence of serine: an often neglected but indispensable amino acid. J. Biol. Chem. 287, 19786–19791 (2012).
5. Furuya, S. An essential role for de novo biosynthesis of l-serine in CNS development. Asia Pac. J. Clin. Nutr. 17 (Suppl. 1), 312–315 (2008).
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