Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase-Reference-Cited by-同舟云学术

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

Published:2011-11-11 Issue:6057 Volume:334 Page:806-809
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Du Jintang¹,Zhou Yeyun²,Su Xiaoyang¹,Yu Jiu Jiu³,Khan Saba¹,Jiang Hong¹,Kim Jungwoo¹,Woo Jimin¹,Kim Jun Huyn¹,Choi Brian Hyun¹,He Bin¹,Chen Wei⁴,Zhang Sheng⁴,Cerione Richard A.¹⁵,Auwerx Johan³,Hao Quan²⁶,Lin Hening¹

Affiliation:

1. Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.

2. MacCHESS, Cornell High Energy Synchrotron Source, Cornell University, Ithaca, NY 14853, USA.

3. Ecole Polytechnique Fédérale de Lausanne (EPFL), Laboratory of Integrative and Systems Physiology, Lausanne CH-1015, Switzerland.

4. Proteomics and Mass Spectrometry Core Facility, Cornell University, Ithaca, NY 14853, USA.

5. Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.

6. Department of Physiology, University of Hong Kong, Hong Kong, China

Abstract

Biological functions of sirtuins may involve lysine desuccinylase and demalonylase activities.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference32 articles.

1. The Biochemistry of Sirtuins

2. Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases

3. Mammalian Sirtuins: Biological Insights and Disease Relevance

4. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

5. Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose

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