A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

Author:

Pejchal Robert1,Doores Katie J.23,Walker Laura M.2,Khayat Reza1,Huang Po-Ssu4,Wang Sheng-Kai5,Stanfield Robyn L.1,Julien Jean-Philippe1,Ramos Alejandra2,Crispin Max6,Depetris Rafael7,Katpally Umesh8,Marozsan Andre8,Cupo Albert8,Maloveste Sebastien9,Liu Yan10,McBride Ryan11,Ito Yukishige12,Sanders Rogier W.713,Ogohara Cassandra4,Paulson James C.11,Feizi Ten10,Scanlan Christopher N.6,Wong Chi-Huey5,Moore John P.7,Olson William C.8,Ward Andrew B.1,Poignard Pascal214,Schief William R.24,Burton Dennis R.23,Wilson Ian A.1

Affiliation:

1. Department of Molecular Biology, Skaggs Institute for Chemical Biology, and International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.

2. Department of Immunology and Microbial Science and IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.

3. Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02129, USA.

4. Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.

5. Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.

6. Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.

7. Weill Medical College of Cornell University, New York, NY 10021, USA.

8. Progenics Pharmaceuticals, Tarrytown, NY 10591, USA.

9. Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

10. Glycosciences Laboratory, Department of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK.

11. Department of Physiological Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.

12. RIKEN Advanced Science Institute and Exploratory Research for Advanced Technology, Japan Science and Technology Agency, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

13. Department of Medical Microbiology, Academic Medical Center, Amsterdam, Netherlands.

14. International AIDS Vaccine Initiative, New York, NY 10038, USA.

Abstract

An HIV antibody achieves potency and breadth by binding simultaneously to two conserved glycans on the viral envelope protein.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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