REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories-Reference-Cited by-同舟云学术

REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories

Published:2019-09-20 Issue:6459 Volume:365 Page:1308-1313
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Izawa Shuntaro¹²³⁴^ORCID,Chowdhury Srikanta¹²³^ORCID,Miyazaki Toh¹²³⁴^ORCID,Mukai Yasutaka¹²³⁴^ORCID,Ono Daisuke¹²³^ORCID,Inoue Ryo¹²^ORCID,Ohmura Yu⁵,Mizoguchi Hiroyuki⁶^ORCID,Kimura Kazuhiro⁷^ORCID,Yoshioka Mitsuhiro⁵,Terao Akira⁷⁸^ORCID,Kilduff Thomas S.⁹^ORCID,Yamanaka Akihiro¹²³^ORCID

Affiliation:

1. Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464-8601, Japan.

2. Department of Neural Regulation, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.

3. CREST, JST, Honcho Kawaguchi, Saitama 332-0012, Japan.

4. JSPS Research Fellowship for Young Scientists, Tokyo 102-0083, Japan.

5. Department of Neuropharmacology, Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan.

6. Research Center for Next-Generation Drug Development, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464-8601, Japan.

7. Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.

8. School of Biological Sciences, Tokai University, Sapporo 005-8601, Japan.

9. Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, CA, USA.

Abstract

A brain pathway for active forgetting Sleep affects memories via several mechanisms. Izawa et al. identified a possible new pathway in the brain: REM sleep–active hypothalamic melanin-concentrating hormone (MCH)–producing neurons, which, among others, project to the hippocampus. Surprisingly, genetic ablation of MCH neurons increased memory performance in mice. Conversely, pharmacogenetic activation of MCH neurons impaired memory. In vitro physiological experiments showed that activation of MCH fibers in hippocampal slices suppressed spiking activity of pyramidal cells. These findings indicate that the MCH pathway may become a target for memory modulation. Science , this issue p. 1308

Funder

MEXT, Japan

JST, CREST

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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