Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax-Reference-Cited by-同舟云学术

Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax

Published:2018-01-05 Issue:6371 Volume:359 Page:48-55
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Gruszczyk Jakub¹^ORCID,Kanjee Usheer²^ORCID,Chan Li-Jin¹³^ORCID,Menant Sébastien¹,Malleret Benoit⁴⁵^ORCID,Lim Nicholas T. Y.¹,Schmidt Christoph Q.⁶,Mok Yee-Foong⁷^ORCID,Lin Kai-Min⁸^ORCID,Pearson Richard D.⁹¹⁰^ORCID,Rangel Gabriel²^ORCID,Smith Brian J.¹¹^ORCID,Call Melissa J.¹³^ORCID,Weekes Michael P.⁸^ORCID,Griffin Michael D. W.⁷,Murphy James M.¹³,Abraham Jonathan¹²,Sriprawat Kanlaya¹³^ORCID,Menezes Maria J.¹⁴,Ferreira Marcelo U.¹⁴,Russell Bruce¹⁵^ORCID,Renia Laurent⁵^ORCID,Duraisingh Manoj T.²,Tham Wai-Hong¹³^ORCID

Affiliation:

1. The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.

2. Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.

3. Department of Medical Biology, The University of Melbourne, Melbourne, Victoria 3010, Australia.

4. Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 117597 Singapore.

5. Singapore Immunology Network, A*STAR, 138648 Singapore.

6. Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, Germany.

7. Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria 3010, Australia.

8. Cambridge Institute for Medical Research, Cambridge CB2 OXY, UK.

9. Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.

10. Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Oxford, UK.

11. La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, Australia.

12. Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.

13. Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.

14. Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

15. Department of Microbiology and Immunology, University of Otago, Dunedin 9054, New Zealand.

Abstract

Vivax malaria host receptor Human malaria is caused by half a dozen species of Plasmodium protozoan parasites, each with distinctive biology. P. vivax , which causes relapsing malaria, specifically parasitizes immature red blood cells called reticulocytes. Gruszczyk et al. identified TfR1 (host transferrin receptor 1) as an alternative receptor for P. vivax . TfR1 binds to a specific P. vivax surface protein. However, the parasite that causes cerebral malaria, P. falciparum , does not share TfR1 as a receptor: P. falciparum could still infect cells in which TfR1 expression was knocked down, but P. vivax could not. Monoclonal antibodies to the P. vivax protein successfully hindered P. vivax infection of red blood cells. Science , this issue p. 48

Funder

Wellcome Trust

Canadian Institutes of Health Research

Australian Research Council

National Health and Medical Research Council

Howard Hughes Medical Institute and Wellcome Trust

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference83 articles.

1. Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations