RIGorous Detection: Exposing Virus Through RNA Sensing-Reference-Cited by-同舟云学术

RIGorous Detection: Exposing Virus Through RNA Sensing

Published:2010-01-15 Issue:5963 Volume:327 Page:284-286
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Rehwinkel Jan¹,Reis e Sousa Caetano¹

Affiliation:

1. Immunobiology Laboratory, Cancer Research UK (CRUK) London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK.

Abstract

Virus infection in mammals elicits a variety of defense responses that are initiated by signals from virus-sensing receptors expressed by the host. These receptors include the ubiquitously expressed RIG-I–like receptor (RLR) family of RNA helicases. RLRs are cytoplasmic proteins that act in cell-intrinsic antiviral defense by recognizing RNAs indicative of virus presence. Here, we highlight recent progress in understanding how RLRs discriminate between the RNA content of healthy versus virus-infected cells, functioning as accurate sensors of virus invasion.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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