The Promise of Comparative Genomics in Mammals-Reference-Cited by-同舟云学术

The Promise of Comparative Genomics in Mammals

Published:1999-10-15 Issue:5439 Volume:286 Page:458-481
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

O'Brien Stephen J.¹,Menotti-Raymond Marilyn¹,Murphy William J.¹,Nash William G.¹,Wienberg Johannes¹,Stanyon Roscoe¹,Copeland Neal G.²,Jenkins Nancy A.²,Womack James E.³,Marshall Graves Jennifer A.⁴

Affiliation:

1. Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702–1201, USA.

2. Mammalian Genetics Laboratory, Advanced BioScience Laboratories, National Cancer Institute, Frederick, MD 21702–1201, USA.

3. Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843, USA.

4. Department of Genetics and Evolution, LaTrobe University, Melbourne, Victoria 3083, Australia.

Abstract

Dense genetic maps of human, mouse, and rat genomes that are based on coding genes and on microsatellite and single-nucleotide polymorphism markers have been complemented by precise gene homolog alignment with moderate-resolution maps of livestock, companion animals, and additional mammal species. Comparative genetic assessment expands the utility of these maps in gene discovery, in functional genomics, and in tracking the evolutionary forces that sculpted the genome organization of modern mammalian species.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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