Comment on “Impaired Respiratory and Body Temperature Control Upon Acute Serotonergic Neuron Inhibition”-Reference-Cited by-同舟云学术

Comment on “Impaired Respiratory and Body Temperature Control Upon Acute Serotonergic Neuron Inhibition”

Published:2012-08-10 Issue:6095 Volume:337 Page:646-646
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Löffler Stefan¹,Körber Jochen²,Nubbemeyer Udo²,Fehsel Karin³

Affiliation:

1. Department of Psychiatry and Psychotherapy, Clinic Offenbach, Teaching Hospital of Goethe University, D-63069 Offenbach, Germany.

2. Department of Organic Chemistry, Gutenberg University, D-55128 Mainz, Germany.

3. Neurobiochemical Research Unit, Clinic and Polyclinic for Psychiatry and Psychotherapy, Heine University, D-40629 Düsseldorf, Germany.

Abstract

Ray et al . (Reports, 29 July 2011, p. 637) assume that clozapine- N 4-oxide (CNO) represents a “biologically inert synthetic ligand” that selectively activates the M4 muscarinic receptor-based DREADD (designer receptor exclusively activated by a designer drug). In contrast, due to the redox cycling of CNO with clozapine and to their cell membrane permeability, CNO is biologically active and its conversion products are capable of undermining DREADD effects.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference33 articles.

1. Impaired Respiratory and Body Temperature Control Upon Acute Serotonergic Neuron Inhibition

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4. Non-enzymatic reduction of aliphatic tertiary amineN-oxides mediated by the haem moiety of cytochrome P450

5. New Insights into the Function of M4 Muscarinic Acetylcholine Receptors Gained Using a Novel Allosteric Modulator and a DREADD (Designer Receptor Exclusively Activated by a Designer Drug)

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