Pharmacokinetic and pharmacodynamic actions of clozapine-N-oxide, clozapine, and compound 21 in DREADD-based chemogenetics in mice-Reference-Cited by-同舟云学术

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Pharmacokinetic and pharmacodynamic actions of clozapine-N-oxide, clozapine, and compound 21 in DREADD-based chemogenetics in mice

Published:2019-03-14 Issue:1 Volume:9 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Jendryka Martin,Palchaudhuri Monika,Ursu Daniel,van der Veen Bastiaan,Liss Birgit,Kätzel Dennis,Nissen Wiebke,Pekcec Anton

Funder

Boehringer Ingelheim Ulm University BioCenter (BIU) project TPN10.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-019-41088-2.pdf

Reference32 articles.

1. Roth, B. L. DREADDs for Neuroscientists. Neuron 89, 683–694, https://doi.org/10.1016/j.neuron.2016.01.040 (2016).

2. Alexander, G. M. et al. Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors. Neuron 63, 27–39, https://doi.org/10.1016/j.neuron.2009.06.014 (2009).

3. Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S. & Roth, B. L. Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proceedings of the National Academy of Sciences of the United States of America 104, 5163–5168, https://doi.org/10.1073/pnas.0700293104 (2007).

4. Pei, Y., Rogan, S. C., Yan, F. & Roth, B. L. Engineered GPCRs as tools to modulate signal transduction. Physiology (Bethesda, Md.) 23, 313–321, https://doi.org/10.1152/physiol.00025.2008 (2008).

5. Tan, E. M. et al. Selective and quickly reversible inactivation of mammalian neurons in vivo using the Drosophila allatostatin receptor. Neuron 51, 157–170, https://doi.org/10.1016/j.neuron.2006.06.018 (2006).

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