Sexual dimorphism in skin immunity is mediated by an androgen-ILC2-dendritic cell axis-Reference-Cited by-同舟云学术

Sexual dimorphism in skin immunity is mediated by an androgen-ILC2-dendritic cell axis

Published:2024-04-12 Issue:6692 Volume:384 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Chi Liang¹^ORCID,Liu Can²^ORCID,Gribonika Inta¹^ORCID,Gschwend Julia³^ORCID,Corral Dan¹,Han Seong-Ji¹,Lim Ai Ing¹^ORCID,Rivera Claudia A.¹,Link Verena M.¹^ORCID,Wells Alexandria C.¹^ORCID,Bouladoux Nicolas¹^ORCID,Collins Nicholas¹,Lima-Junior Djalma S.¹^ORCID,Enamorado Michel¹^ORCID,Rehermann Barbara⁴^ORCID,Laffont Sophie⁵^ORCID,Guéry Jean-Charles⁵^ORCID,Tussiwand Roxane⁶^ORCID,Schneider Christoph³^ORCID,Belkaid Yasmine¹⁷^ORCID

Affiliation:

1. Metaorganism Immunity Section, Laboratory of Host Immunity and Microbiome, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

2. Multiscale Systems Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

3. Institute of Physiology, University of Zurich, CH-8057 Zürich, Switzerland.

4. Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

5. Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM UMR1291, CNRS UMR5051, University Toulouse III, Toulouse, France.

6. National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

7. NIAID Microbiome Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

Males and females exhibit profound differences in immune responses and disease susceptibility. However, the factors responsible for sex differences in tissue immunity remain poorly understood. Here, we uncovered a dominant role for type 2 innate lymphoid cells (ILC2s) in shaping sexual immune dimorphism within the skin. Mechanistically, negative regulation of ILC2s by androgens leads to a reduction in dendritic cell accumulation and activation in males, along with reduced tissue immunity. Collectively, our results reveal a role for the androgen-ILC2-dendritic cell axis in controlling sexual immune dimorphism. Moreover, this work proposes that tissue immune set points are defined by the dual action of sex hormones and the microbiota, with sex hormones controlling the strength of local immunity and microbiota calibrating its tone.

Publisher

American Association for the Advancement of Science (AAAS)

Link

https://www.science.org/doi/pdf/10.1126/science.adk6200

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