Estrogen receptor α contributes to T cell–mediated autoimmune inflammation by promoting T cell activation and proliferation

Author:

Mohammad Imran12ORCID,Starskaia Inna12,Nagy Tamas3,Guo Jitao1,Yatkin Emrah4,Väänänen Kalervo5,Watford Wendy T.6ORCID,Chen Zhi1ORCID

Affiliation:

1. Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku 20520, Finland.

2. Turku Doctoral Programme of Molecular Medicine, University of Turku, Turku, Finland.

3. Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.

4. Turku Central Animal Laboratory, University of Turku, Turku 20520, Finland.

5. Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku, Turku 20520, Finland.

6. Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.

Abstract

Estrogen receptor α promotes T cell activation and exacerbates autoimmune disease.

Funder

NIH

Academy of Finland

CIMO

University of Turku Foundation

institutional funds provided by the Office of the Vice President for Research at the University of Georgia

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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