Structural basis for antibody inhibition of flavivirus NS1–triggered endothelial dysfunction-Reference-Cited by-同舟云学术

Structural basis for antibody inhibition of flavivirus NS1–triggered endothelial dysfunction

Published:2021-01-08 Issue:6525 Volume:371 Page:194-200
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Biering Scott B.¹^ORCID,Akey David L.²^ORCID,Wong Marcus P.¹³^ORCID,Brown W. Clay²,Lo Nicholas T. N.¹³,Puerta-Guardo Henry¹^ORCID,Tramontini Gomes de Sousa Francielle¹^ORCID,Wang Chunling¹,Konwerski Jamie R.²^ORCID,Espinosa Diego A.¹^ORCID,Bockhaus Nicholas J.²⁴^ORCID,Glasner Dustin R.¹^ORCID,Li Jeffrey¹^ORCID,Blanc Sophie F.¹^ORCID,Juan Evan Y.¹,Elledge Stephen J.⁵^ORCID,Mina Michael J.⁶^ORCID,Beatty P. Robert¹^ORCID,Smith Janet L.²⁴^ORCID,Harris Eva¹^ORCID

Affiliation:

1. Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA.

2. Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

3. Infectious Diseases and Immunity Graduate Group, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA.

4. Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

5. Division of Genetics, Brigham and Women’s Hospital, Howard Hughes Medical Institute, Department of Genetics, and Program in Virology, Harvard Medical School, Boston, MA 02115, USA.

6. Center for Communicable Disease Dynamics, Department of Epidemiology, and Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA.

Abstract

Two antibodies against flaviviruses Flaviviruses are a group of RNA viruses that include the human pathogens dengue virus, Zika virus, and West Nile virus. The envelope protein (E) on the virus surface has been the target of vaccine development, but problems have arisen with antibodies against E, leading to enhanced infection. Now, Modhiran et al. and Biering et al. describe two different antibodies that bind to the flavivirus NS1 protein and prevent it from disrupting epithelial cells, which is associated with severe disease. Both antibodies cross-react with multiple flavivirus NS1 proteins. The antibodies reduce viremia and increase survival in mouse models of flavivirus disease. Both papers include structures of NS1 bound to an antibody, which give insight into the protective mechanism. Science , this issue p. 190 , p. 194

Funder

Bill and Melinda Gates Foundation

NIAID

Value of Vaccine Research Network

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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