NAD + cleavage activity by animal and plant TIR domains in cell death pathways-Reference-Cited by-同舟云学术

NAD + cleavage activity by animal and plant TIR domains in cell death pathways

Published:2019-08-23 Issue:6455 Volume:365 Page:793-799
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Horsefield Shane¹^ORCID,Burdett Hayden¹^ORCID,Zhang Xiaoxiao²³^ORCID,Manik Mohammad K.¹,Shi Yun⁴^ORCID,Chen Jian²³^ORCID,Qi Tiancong⁵,Gilley Jonathan⁶⁷,Lai Jhih-Siang¹^ORCID,Rank Maxwell X.¹^ORCID,Casey Lachlan W.¹⁸^ORCID,Gu Weixi¹,Ericsson Daniel J.⁹^ORCID,Foley Gabriel¹^ORCID,Hughes Robert O.¹⁰,Bosanac Todd¹⁰,von Itzstein Mark⁴^ORCID,Rathjen John P.³^ORCID,Nanson Jeffrey D.¹,Boden Mikael¹^ORCID,Dry Ian B.¹¹^ORCID,Williams Simon J.³^ORCID,Staskawicz Brian J.⁵^ORCID,Coleman Michael P.⁶⁷,Ve Thomas¹⁴^ORCID,Dodds Peter N.²^ORCID,Kobe Bostjan¹^ORCID

Affiliation:

1. School of Chemistry and Molecular Biosciences, Institute for Molecular Bioscience and Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, QLD 4072, Australia.

2. Agriculture and Food, Commonwealth Scientific and Industrial Research Organisation, Canberra, ACT 2601, Australia.

3. Plant Sciences Division, Research School of Biology, The Australian National University, Canberra ACT 2601, Australia.

4. Institute for Glycomics, Griffith University, Southport, QLD 4222, Australia.

5. Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA 94720, USA.

6. John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, ED Adrian Building, Forvie Site, Robinson Way, Cambridge CB2 0PY, UK.

7. Babraham Institute, Babraham, Cambridge CB22 3AT, UK.

8. Centre for Microscopy and Microanalysis, University of Queensland, Brisbane, QLD 4072, Australia.

9. Macromolecular Crystallography (MX) Beamlines, Australian Synchrotron, Melbourne, VIC 3168, Australia.

10. Disarm Therapeutics, 400 Technology Square, Cambridge, MA 02139, USA.

11. Agriculture and Food, Commonwealth Scientific and Industrial Research Organisation, Urrbrae, SA 5064, Australia.

Abstract

NAD depletion as pathogen response One way that plants respond to pathogen infection is by sacrificing the infected cells. The nucleotide-binding leucine-rich repeat immune receptors responsible for this hypersensitive response carry Toll/interleukin-1 receptor (TIR) domains. In two papers, Horsefield et al. and Wan et al. report that these TIR domains cleave the metabolic cofactor nicotinamide adenine dinucleotide (NAD + ) as part of their cell-death signaling in response to pathogens. Similar signaling links mammalian TIR-containing proteins to NAD + depletion during Wallerian degeneration of neurons. Science , this issue p. 793 , p. 799

Funder

Australian Research Council

National Health and Medical Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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