Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA

Author:

Lucifora Julie12,Xia Yuchen1,Reisinger Florian1,Zhang Ke1,Stadler Daniela1,Cheng Xiaoming1,Sprinzl Martin F.13,Koppensteiner Herwig1,Makowska Zuzanna4,Volz Tassilo5,Remouchamps Caroline6,Chou Wen-Min1,Thasler Wolfgang E.7,Hüser Norbert8,Durantel David9,Liang T. Jake10,Münk Carsten11,Heim Markus H.4,Browning Jeffrey L.12,Dejardin Emmanuel6,Dandri Maura25,Schindler Michael1,Heikenwalder Mathias1,Protzer Ulrike12

Affiliation:

1. Institute of Virology, Technische Universität München–Helmholtz Zentrum München, 81675 Munich, Germany.

2. German Center for Infection Research (DZIF), Munich and Hamburg sites, Germany.

3. 1st Medical Department, University Hospital Mainz, 55131 Mainz, Germany.

4. Department of Biomedicine, University Hospital Basel, 4031 Basel, Switzerland.

5. Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

6. GIGA-Research Laboratory of Molecular Immunology and Signal Transduction, University of Liège, 4000 Liège, Belgium.

7. Department of General, Visceral, Transplantation, Vascular and Thoracic Surgery, Grosshadern Hospital, Ludwig Maximilians University, 81377 Munich, Germany.

8. Department of Surgery, University Hospital Rechts der Isar, Technische Universität München, 85748 Munich, Germany.

9. INSERM U1052, CNRS UMR 5286, Cancer Research Center of Lyon, University of Lyon, LabEx DEVweCAN, 69007 Lyon, France.

10. Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.

11. Clinic for Gastroenterology, Hepatology and Infectiology, Medical Faculty, Heinrich-Heine University, 40225 Düsseldorf, Germany.

12. Department of Immunobiology, Biogen Idec, Cambridge, MA 02142, USA.

Abstract

Clearance of Chronic Virus The family of mRNA-editing enzymes, APOBEC, restricts hepatitis B virus (HBV) replication. Lucifora et al. (p. 1221 , published online 20 February; see the Perspective by Shlomai and Rice ) provide evidence that specific APOBECs mediate the anti-HBV effects of host cytokines, which in turn apparently induce nuclear deaminase activity without damaging host cells. Thus, there may be potential in these findings for developing a therapeutic route to curing chronic HBV infection.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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