Impact of cytosine methylation on DNA binding specificities of human transcription factors-Reference-Cited by-同舟云学术

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Published:2017-05-05 Issue:6337 Volume:356 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Yin Yimeng¹^ORCID,Morgunova Ekaterina¹^ORCID,Jolma Arttu¹^ORCID,Kaasinen Eevi¹,Sahu Biswajyoti²^ORCID,Khund-Sayeed Syed³,Das Pratyush K.²^ORCID,Kivioja Teemu²^ORCID,Dave Kashyap¹^ORCID,Zhong Fan¹,Nitta Kazuhiro R.¹^ORCID,Taipale Minna¹^ORCID,Popov Alexander⁴^ORCID,Ginno Paul A.⁵,Domcke Silvia⁵⁶,Yan Jian¹^ORCID,Schübeler Dirk⁵⁶,Vinson Charles³^ORCID,Taipale Jussi¹²^ORCID

Affiliation:

1. Division of Functional Genomics and Systems Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 141 83 Stockholm, Sweden.

2. Genome-Scale Biology Program, Post Office Box 63, FI-00014 University of Helsinki, Helsinki, Finland.

3. Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Room 3128, Building 37, Bethesda, MD 20892, USA.

4. European Synchrotron Radiation Facility, 38043 Grenoble, France.

5. Friedrich-Miescher-Institute for Biomedical Research (FMI), Maulbeerstrasse 66, 4058 Basel, Switzerland.

6. Faculty of Science, University of Basel, Petersplatz 1, 4003 Basel, Switzerland.

Abstract

Positives and negatives of methylated CpG When the DNA bases cytosine and guanine are next to each other, a methyl group is generally added to the pyrimidine, generating a mCpG dinucleotide. This modification alters DNA structure but can also affect function by inhibiting transcription factor (TF) binding. Yin et al. systematically analyzed the effect of CpG methylation on the binding of 542 human TFs (see the Perspective by Hughes and Lambert). In addition to inhibiting binding of some TFs, they found that mCpGs can promote binding of others, particularly TFs involved in development, such as homeodomain proteins. Science , this issue p. eaaj2239 ; see also p. 489

Funder

Academy of Finland Center of Excellence in Cancer Genetics

European Research Area SynBio

Center for Innovative Medicine at Karolinska Institutet

Knut and Alice Wallenberg Foundation

Göran Gustafsson Foundation

Vetenskapsrådet

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference94 articles.