Transformation of Tooth Type Induced by Inhibition of BMP Signaling-Reference-Cited by-同舟云学术

Transformation of Tooth Type Induced by Inhibition of BMP Signaling

Published:1998-11-06 Issue:5391 Volume:282 Page:1136-1138
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Tucker Abigail S.¹,Matthews Karen L.¹,Sharpe Paul T.¹

Affiliation:

1. Department of Craniofacial Development, Guy's, King's, and St. Thomas' School of Dentistry, Guy's Hospital, London SE1 9RT, UK.

Abstract

Mammalian dentitions are highly patterned, with different types of teeth positioned in different regions of the jaws. BMP4 is an early oral epithelial protein signal that directs odontogenic gene expression in mesenchyme cells of the developing mandibular arch. BMP4 was shown to inhibit expression of the homeobox gene Barx-1 and to restrict expression to the proximal, presumptive molar mesenchyme of mouse embryos at embryonic day 10. The inhibition of BMP signaling early in mandible development by the action of exogenous Noggin protein resulted in ectopic Barx-1 expression in the distal, presumptive incisor mesenchyme and a transformation of tooth identity from incisor to molar.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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5. Mandibular arch explants were dissected and cultured as described (3). Beads were also prepared as described (3 4) with Fgf8 and BSA (white) and BMP4 and Noggin (blue) beads at a concentration of 100 μg/mg. Whole-mount digoxigenin (DIG) and sectioned 35 S in situ hybridization were carried out as described (3 4).

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