CRISPR-Cas: Adapting to change-Reference-Cited by-同舟云学术

CRISPR-Cas: Adapting to change

Published:2017-04-07 Issue:6333 Volume:356 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Jackson Simon A.¹^ORCID,McKenzie Rebecca E.²^ORCID,Fagerlund Robert D.¹^ORCID,Kieper Sebastian N.²^ORCID,Fineran Peter C.¹³^ORCID,Brouns Stan J. J.²⁴^ORCID

Affiliation:

1. Department of Microbiology and Immunology, University of Otago, Post Office Box 56, Dunedin 9054, New Zealand.

2. Department of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, Netherlands.

3. Bio-Protection Research Centre, University of Otago, Post Office Box 56, Dunedin 9054, New Zealand.

4. Laboratory of Microbiology, Wageningen University, Wageningen, Netherlands.

Abstract

Variation in prokaryote adaptive immunity To repel infection by phage and mobile genetic elements, prokaryotes have a form of adaptive immune response and memory invested in clustered regularly interspaced short palindromic repeats and associated proteins (CRISPR-Cas). This molecular machinery can recognize and remember foreign nucleic acids by capturing and retaining small nucleotide sequences. On subsequent encounters, the cognate CRISPR-Cas marshals enzymatic defenses to destroy infecting elements that contain the same sequences. Jackson et al. review the molecular mechanisms by which diverse CRISPR-Cas systems adapt and anticipate novel threats and evasive countermeasures from mobile genetic elements. Science , this issue p. eaal5056

Funder

European Research Council

Netherlands Organisation for Scientific Research (NWO) Vidi

Foundation for Fundamental Research on Matter (FOM)

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference108 articles.

1. Remarkable Mechanisms in Microbes to Resist Phage Infections

2. Revenge of the phages: defeating bacterial defences

3. CRISPR-Cas immunity in prokaryotes