Deep conservation of the enhancer regulatory code in animals-Reference-Cited by-同舟云学术

Deep conservation of the enhancer regulatory code in animals

Published:2020-11-06 Issue:6517 Volume:370 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Wong Emily S.¹²³^ORCID,Zheng Dawei²^ORCID,Tan Siew Z.⁴^ORCID,Bower Neil I.⁴^ORCID,Garside Victoria⁵^ORCID,Vanwalleghem Gilles⁶^ORCID,Gaiti Federico¹^ORCID,Scott Ethan⁶^ORCID,Hogan Benjamin M.⁴⁷^ORCID,Kikuchi Kazu²,McGlinn Edwina⁵^ORCID,Francois Mathias⁴⁸^ORCID,Degnan Bernard M.¹^ORCID

Affiliation:

1. School of Biological Sciences, University of Queensland, Brisbane, Australia.

2. Victor Chang Cardiac Research Institute, Sydney, Australia.

3. School of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, Australia.

4. Institute for Molecular Biosciences, University of Queensland, Brisbane, Australia.

5. Australian Regenerative Medicine Institute, Monash University, Melbourne, Australia.

6. Queensland Brain Institute, University of Queensland, Brisbane, Australia.

7. Department of Anatomy and Neuroscience and Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia.

8. Centenary Institute, David Richmond Program for Cardio-Vascular Research: Gene Regulation and Editing, School of Life and Environmental Sciences, University of Sydney, Sydney, Australia.

Abstract

Enhancer function, from sponges to humans Identifying the function of enhancers, DNA regions that help to regulate gene expression and evolve rapidly, has been difficult. This area of research has been hampered by the difficultly in identifying functional conservation. Wong et al. now show that despite low sequence conservation, enhancer function is strongly conserved through the animal kingdom (see the Perspective by Harmston). Transgenic expression of sponge enhancers in zebrafish and mice demonstrates that these sequences can drive cell type–specific gene expression across species. These results suggest an unexpectedly deep level of conservation of gene regulation across the animal kingdom maintained over the course of metazoan evolution. Science , this issue p. eaax8137 ; see also p. 657

Funder

Australian Research Council

National Health and Medical Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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