Multigenerational Cortical Inheritance of the Rax2 Protein in Orienting Polarity and Division in Yeast-Reference-Cited by-同舟云学术

Multigenerational Cortical Inheritance of the Rax2 Protein in Orienting Polarity and Division in Yeast

Published:2000-12-08 Issue:5498 Volume:290 Page:1975-1978
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Chen Tracy¹,Hiroko Takatoshi²,Chaudhuri Amitabha¹,Inose Fumika²,Lord Matthew¹,Tanaka Shigeko²,Chant John¹,Fujita Atsushi²

Affiliation:

1. Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.

2. National Institute of Bioscience & Human Technology, AIST 1-1 Higashi, Tsukuba 305-8566, Japan.

Abstract

Diploid yeast cells repeatedly polarize and bud from their poles, probably because of highly stable marks of unknown composition. Here, Rax2, a membrane protein, was shown to behave as such a mark. The Rax2 protein itself was inherited immutably at the cell cortex for multiple generations, and Rax2 was shown to have a half-life exceeding several generations. The persistent inheritance of cortical protein markers would provide a means to couple a cell's history to the future development of a precise morphogenetic form.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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