Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation-Reference-Cited by-同舟云学术

Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation

Published:2012-09-21 Issue:6101 Volume:337 Page:1541-1546
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Dey Anwesha¹,Seshasayee Dhaya²,Noubade Rajkumar²,French Dorothy M.³,Liu Jinfeng⁴,Chaurushiya Mira S.¹,Kirkpatrick Donald S.⁵,Pham Victoria C.⁵,Lill Jennie R.⁵,Bakalarski Corey E.⁴,Wu Jiansheng⁵,Phu Lilian⁵,Katavolos Paula⁶,LaFave Lindsay M.⁷,Abdel-Wahab Omar⁷,Modrusan Zora⁸,Seshagiri Somasekar⁸,Dong Ken⁹,Lin Zhonghua¹⁰,Balazs Mercedesz¹⁰,Suriben Rowena¹,Newton Kim¹,Hymowitz Sarah⁹,Garcia-Manero Guillermo¹¹,Martin Flavius²,Levine Ross L.⁷,Dixit Vishva M.¹

Affiliation:

1. Department of Physiological Chemistry, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

2. Department of Immunology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

3. Department of Pathology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

4. Department of Bioinformatics and Computational Biology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

5. Department of Protein Chemistry, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

6. Department of Safety Assessment, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

7. Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

8. Department of Molecular Biology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

9. Department of Structural Biology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

10. Department of Translational Immunology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

11. MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

Abstract

Identifying BAP1 Targets Inactivating mutations in the deubiquitinating enzyme BAP1 have been associated with cancer. Dey et al. (p. 1541 , published online 9 August; see the Perspective by

White and Harper

) reveal molecular targets of the enzyme and show evidence for a role in leukemia. Mice specifically lacking the target of BAP1, HCF-1, in the bone marrow developed myeloid leukemia. BAP1 appears to be part of a complex that regulates modification of histones and gene expression important for normal hematopoiesis and tumor suppression.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference25 articles.

1. Frequent Mutation of BAP1 in Metastasizing Uveal Melanomas

2. BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression

3. Defining biochemical functions for the BRCA1 tumor suppressor protein: analysis of the BRCA1 binding protein BAP1

4. Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma

5. Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers

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