A human cell atlas of fetal gene expression-Reference-Cited by-同舟云学术

A human cell atlas of fetal gene expression

Published:2020-11-13 Issue:6518 Volume:370 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Cao Junyue¹^ORCID,O’Day Diana R.²^ORCID,Pliner Hannah A.³^ORCID,Kingsley Paul D.⁴^ORCID,Deng Mei²^ORCID,Daza Riza M.¹^ORCID,Zager Michael A.³⁵^ORCID,Aldinger Kimberly A.²⁶^ORCID,Blecher-Gonen Ronnie¹^ORCID,Zhang Fan⁷^ORCID,Spielmann Malte⁸⁹^ORCID,Palis James⁴^ORCID,Doherty Dan²³⁶^ORCID,Steemers Frank J.⁷,Glass Ian A.²³⁶^ORCID,Trapnell Cole¹³¹⁰^ORCID,Shendure Jay¹³¹⁰¹¹^ORCID

Affiliation:

1. Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.

2. Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA.

3. Brotman Baty Institute for Precision Medicine, Seattle, WA, USA.

4. Department of Pediatrics, University of Rochester Medical Center, Rochester, NY, USA.

5. Center for Data Visualization, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

6. Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.

7. Illumina Inc., San Diego, CA, USA.

8. Human Molecular Genomics Group, Max Planck Institute for Molecular Genetics, Berlin, Germany.

9. Institute of Human Genetics, University of Lübeck, Lübeck, Germany.

10. Allen Discovery Center for Cell Lineage Tracing, Seattle, WA, USA.

11. Howard Hughes Medical Institute, Seattle, WA, USA.

Abstract

The genomics of human development Understanding the trajectory of a developing human requires an understanding of how genes are regulated and expressed. Two papers now present a pooled approach using three levels of combinatorial indexing to examine the single-cell gene expression and chromatin landscapes from 15 organs in fetal samples. Cao et al. focus on measurements of RNA in broadly distributed cell types and provide insights into organ specificity. Domcke et al. examined the chromatin accessibility of cells from these organs and identify the regulatory elements that regulate gene expression. Together, these analyses generate comprehensive atlases of early human development. Science , this issue p. eaba7721 , p. eaba7612

Funder

National Institutes of Health

Howard Hughes Medical Institute

NIH Office of the Director

Deutsche Forschungsgemeinschaft

Paul G. Allen Frontiers Foundation

Brotman Baty Institute for Precision Medicine

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference206 articles.