Oxidative N -Dealkylation: A Mannich Intermediate in the Formation of a New Metabolite of Lidocaine in Man
Author:
Affiliation:
1. Department of Pharmaceutical Chemistry, University of California San Francisco Medical Center, San Francisco 94122
Publisher
American Association for the Advancement of Science (AAAS)
Subject
Multidisciplinary
Reference9 articles.
1. BECKETT, A. H., JOURNAL OF PHARMACY AND PHARMACOLOGY 18: S76 (1966).
2. BRODIE, B.B., DETOXICATION OF DRUGS AND OTHER FOREIGN COMPOUNDS BY LIVER MICROSOMES, SCIENCE 121: 603 (1955).
3. Budzikiewicz, H., Mass Spectrometry of Organic Compounds: 297 (1967).
4. CARRINGTON, H. C., JOURNAL OF THE CHEMICAL SOCIETY: 1017 (1954).
5. CARRINGTON, H.C., A METABOLITE OF PALUDRINE WITH HIGH ANTIMALARIAL ACTIVITY, NATURE 168: 1080 (1951).
Cited by 42 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Discovery of a Novel Lidocaine Metabolite by Human Liver Microsome and Identification of Microbial Species Which Produces the Same Metabolite;Chemical and Pharmaceutical Bulletin;2024-04-19
2. Regioselectivity of CH activation in cytochrome P450‐catalyzed intramolecular cyclization of alkylamine compounds;International Journal of Quantum Chemistry;2023-07-04
3. Nanoporous Gold Catalyst for the Oxidative N‐Dealkylation of Drug Molecules: A Method for Synthesis of N‐Dealkylated Metabolites;ChemMedChem;2022-04-05
4. Mechanistic studies on the drug metabolism and toxicity originating from cytochromes P450;Drug Metabolism Reviews;2020-07-02
5. Is there enough evidence to classify cycloalkyl amine substituents as structural alerts?;Biochemical Pharmacology;2020-04
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3