Affiliation:
1. East-Siberian Institute of Medical and Ecological Research
Abstract
Endothelial dysfunction plays an important role in the pathogenesis of cardiovascular diseases. Genetic predisposition, metabolic disorders and other effects, including occupational hazards, can lead to the formation of endothelial dysfunction. The study aims to assess the role of polymorphisms of candidate genes of endothelial dysfunction and metabolic disorders in the development of cardiovascular diseases in persons with occupational pathology. Scientists have found that the carriage of certain alleles of polymorphisms G894T of the endothelial nitric oxide synthase gene, Lys198Asp and G8002A of endothelin-1, Met235Thr and Thr174Met of the angiotensinogen gene, -2548G/A, 19G/A and G2453A of leptin, 668A/G and Gln223Arg of the leptin receptor, determining the structure of proteins-markers of endothelial dysfunction and metabolic syndrome, as well as some production factors (exposure to vibration, exposure to vinyl chloride, mercury, fluorine and aluminum compounds), all these are in close connection with the development of cardiovascular diseases in persons with occupational pathology.
Publisher
FSBI Research Institute of Occupational Health RAMS
Reference45 articles.
1. Shishkin A.N., Lyndina M.L. Endothelial dysfunction, metabolic syndrome and microalbuminuria. Nefrologija. 2009; 13(3): 24–32 (in Russian).
2. Islamgaleeva Z.M., Mingazetdinova L.N., Kabilova A.V., Bakirov A.B. Interdependence of endothelial dysfunction with polymorphism of SELP and VEGF genes in women with metabolic syndrome and arterial hypertension. Medicinskij vestnik Bashkortostana. 2017; 6(72): 21–6 (in Russian).
3. da Silva A.A., do Carmo J.M., Li X., Wang Z., Mouton A.J., Hall J.E. Role of hyperinsulinemia and insulin resistance in hypertension: metabolic syndrome revisited. Can J Cardiol. 2020; 36(5): 671–82.
4. Kudaeva I.V., Dyakovich O.A., Katamanova E.V., Eshhina I.M. Impact of cardiovascular risk genes polymorphism in the development of metabolic disorders in persons exposed to vinyl chloride. Gigiena i sanitarija. 2019; 98(10): 1113–8 (in Russian).
5. Timasheva G.V., Bakirov A.B., Valeeva E.T., Sakiev K.Z., Repina E.F., Myshkin V.A. et al. Diagnostic value of laboratory markers for assessing metabolic disorders in the body when exposed to chemical pollutants at work. Gigiena truda i medicinskaja jekologija. 2016; 1(50): 81–88 (in Russian).
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献