Studies of personality at work have made significant contributions to theory and applied practice in work and organizational settings. This review article proposes that there are also reciprocal influences between core personality science and research on personality in work and organizations, each drawing on insights from the other. Following this tradition, the objective of this article is to review key foundations of research in a way that informs and critically reflects on state-of-the-art evidence in four main themes: (1) conceptualization and structure of personality at work, (2) personality assessment in work settings, (3) personality processes and dynamics at work, and (4) impact of situations on personaliy at work. Critically reflections on key implications, and directions for future research are presented, anticipating how the field may adapt to the changing nature of work and society.