SLC6A3 Is Associated With Relational Aggression in Children

Abstract

Abstract. Understanding the genetic influence on aggressive behavior in children is one way to understand pathways to the development of aggression in adults. While aggression is likely under some environmental influence, it is also likely under some genetic influence. Overt aggression associates with a variety of genes including dopaminergic and serotonergic genes. Dopaminergic and serotonergic genes are known to be associated with overt aggression. However, little is known regarding the genetic pathways associated with relational aggression. Detecting genetic associates of relational aggression is important to eventually understand pathways to socially aggressive behaviors in children. Therefore, we attempted to determine if relational aggression was also associated with dopaminergic and serotonergic genes. We invited the parents of 327 children to complete a modified version of the MacArthur Health and Behavior Questionnaire (HBQ-P), which has a subscale for relational aggression. We used logistic regression models that predicted relational aggression after controlling for covariates. One genetic predictor was added at a time until there was no model improvement. The covariates were overt aggression scores obtained from the HBQ-P and age. The final (best) model included as a significant predictor of relational aggression one single nucleotide polymorphisms (SNP) on SLC6A3 (rs2617605) and the covariates.