S-Equol Enantioselectively Activates cAMP-Protein Kinase A Signaling and Reduces Alloxan-Induced Cell Death in INS-1 Pancreatic ^|^beta;-Cells

Author:

HORIUCHI Hiroko,HARADA Naoki,ADACHI Tetsuya,NAKANO Yoshihisa,INUI Hiroshi,YAMAJI Ryoichi

Publisher

Center for Academic Publications Japan

Subject

Nutrition and Dietetics,Medicine (miscellaneous)

Reference36 articles.

1. 1) Setchell KD, Clerici C. 2010. Equol: history, chemistry, and formation. J Nutr 140: 1355S-1362S.

2. 2) Morito K, Hirose T, Kinjo J, Hirakawa T, Okawa M, Nohara T, Ogawa S, Inoue S, Muramatsu M, Masamune Y. 2001. Interaction of phytoestrogens with estrogen receptors α and β. Biol Pharm Bull 24: 351-356.

3. 3) Shinkaruk S, Carreau C, Flouriot G, Bennetau-Pelissero C, Potier M. 2010. Comparative effects of R- and S-equol and implication of transactivation functions (AF-1 and AF-2) in estrogen receptor-induced transcriptional activity. Nutrients 2: 340-354.

4. 4) Muthyala RS, Ju YH, Sheng S, Williams LD, Doerge DR, Katzenellenbogen BS, Helferich WG, Katzenellenbogen JA. 2004. Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta. Bioorg Med Chem 12: 1559-1567.

5. 5) Liang XL, Wang XL, Li Z, Hao QH, Wang SY. 2010. Improved in vitro assays of superoxide anion and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity of isoflavones and isoflavone metabolites. J Agric Food Chem 58: 11548-11552.

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