Cancer-Stem-Cell Phenotype-Guided Discovery of a Microbiota-Inspired Synthetic Compound Targeting NPM1 for Leukemia

Author:

Algar Sergio1ORCID,Vázquez-Villa Henar1ORCID,Aguilar-Garrido Pedro23,Navarro-Aguadero Miguel Ángel23,Velasco-Estévez María23,Sánchez-Merino Anabel1,Arribas-Álvarez Iván1,Paradela Alberto4ORCID,Giner-Arroyo Rafael L.5,Tamargo-Azpilicueta Joaquín5ORCID,Díaz-Moreno Irene5,Martínez-López Joaquín23,Gallardo Miguel23,López-Rodríguez María L.1ORCID,Benhamú Bellinda1ORCID

Affiliation:

1. Department of Organic Chemistry, Faculty of Chemistry, Universidad Complutense de Madrid, E-28040 Madrid, Spain

2. Department of Haematology, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), E-28041 Madrid, Spain

3. H12O-CNIO Haematological Malignancies Clinical Research Unit, Spanish National Cancer Research Centre, E-28029 Madrid, Spain

4. Proteomics Laboratory, CNB, CSIC, E-28049 Madrid, Spain

5. Institute for Chemical Research, cicCartuja, University of Seville, CSIC, E-41092 Sevilla, Spain

Funder

Junta de Andaluc?a

Fundaci?n Ram?n Areces

Universidad Complutense de Madrid

Ministerio de Ciencia e Innovaci?n

Universidad de Sevilla

HORIZON EUROPE Marie Sklodowska-Curie Actions

Instituto de Salud Carlos III

Fundaci?n Espa?ola de Hematolog?a y Hemoterapia

CRIS Cancer Foundation

Publisher

American Chemical Society (ACS)

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