A Mechanistic Study of Analgesic and Anticancer Activity of unexplored plant Strobilanthes Kunthiana Phytocosntituents using Molecular Docking Studies.

Abstract

Abstract Background: Cancer is one of the leading causes of death worldwide, and the pain associated with it is very intense. Plants are a significant source of medications, particularly anticancer and analgesic medicines. One significant plant, Strobilanthes Kunthiana, is well-known for its assortment of medical applications. As a result, additional studies were carried out using these two Phytocosntituents, lupeol and betulin, to examine their analgesic and anticancer characteristics using PDB IDs 2MUB and 4XI3. The examination on the basis of molecular docking and ADME profiles served as the foundation for this study. Objective: Based on molecular docking investigations, to suggest a mechanism of Strobilanthes Kunthiana Phytocosntituents for anticancer and analgesic activity. Method: Molecular docking studies of Phytoconstituents of Strobilanthes Kunthiana were performed using the PyRx Virtual Screening software. Results:According to the results of molecular docking, numerous ingredients, such as lupeol and betulin exhibit higher dock scores better than standard medications against analgesic and anticancer targets. Conclusion: Based on molecular docking studies. Various chemical constituents may act as effective inhibitors of various proteins 2MUB, 4XI3. This information can be used to design new anticancer medicines.