Affiliation:
1. University Institute of Pharma sciences, Chandigarh University Gharuan, Mohali, 140413, India
Abstract
Background:
Diabetes mellitus is a significant medical condition with rising incidence
and fatality rates. According to WHO, around 422 million individuals globally have diabetes, the
majority of whom live in low and middle-income economies. Diabetes is entirely responsible for 1.5
million fatalities yearly. Researchers are concentrating on plant derivatives due to the higher toxicity
of conventional allopathic medicines. Antidiabetic agents and other medications, including from
plants, are significant. Pyracantha crenulata is a significant plant recognized for its various therapeutic
applications. It contains many phytoconstituents that give antidiabetic efficiency. In order to
investigate the antidiabetic efficacy of Pyracantha crenulata phytoconstituents, a study was conducted
using PDB IDs IUOK. The research was focused on the analysis of molecular docking and ADME
and toxicity studies.
Objective:
This study aimed to propose a mechanism for the antidiabetic activity of Pyracantha
crenulata phytoconstituents based on molecular docking studies.
Method:
The phytoconstituents of Pyracantha crenulata were docked using the PyRx Virtual
Screening software, and the ADME study was evaluated.
Results:
The results of molecular docking showed that many phytocosntituents of Pyracantha crenulata
have higher dock scores against antidiabetic action than conventional drugs.
Conclusion:
Based on molecular docking study, different chemical constituents may act as potent
inhibitors of diabetic proteins IUOK. By using the outcome of the research, new anti-diabetic medications
could be designed.
Publisher
Bentham Science Publishers Ltd.
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