Abstract
Abstract
This study was designed to examine the effects of trace elements on inflammation and antioxidant capacity in rats with high-sucrose diet. Wistar rats were randomly divided into four groups: Group I, control diet; group II, control diet + trace elements; group III, high-sucrose diet; group IV, high-sugar diet + trace elements. While the animals were fed, rats in group II and group IV were given a supplement of eleven kinds of trace elements including boron, vanadium, chromium, manganese, iron, cobalt, copper, zinc, selenium, strontium and molybdenum by gavage every day, whereas others were injected with physiological saline. At 4, 8, 12 and 20 weeks, the changes of oxidative stress and inflammatory markers at each time point were evaluated. The results showed that the high-sucrose diet rats induced a noticeable increase in body weight, blood glucose, and significantly caused oxidative stress and inflammation. In addition, the trace elements supplement significantly reduced the trace element deficiency and high-sucrose diet induced by the rise of interleukin-6 and tumor necrosis factor-α, but promoted the secretion of interleukin-4 and interleukin-10. Secondly, supplementation of trace elements can inhibit the decrease of catalase, total superoxide dismutase and glutathione peroxidase activities in serum and spleen of rats with high- sucrose diet, improve the level of glutathione and total antioxidant capacity, and reduce the production of malondialdehyde. Finally, micronutrient balance can prevent weight gain caused by high-sucrose diet in rats.
Publisher
Research Square Platform LLC