KIF5A inhibition ferroptosis in Parkinson's disease

Author:

Wu Peipei1,Wu Chunxiao1,Han Jiajun1,Huang Zifeng1,Hao Xiaoqian1,Zhao Lijun1,Chen Dongfeng2,Zhu Meiling1

Affiliation:

1. Traditional Chinese Medicine Innovation Research Center, Guangzhou University of Chinese Medicine

2. Guangzhou University of Chinese Medicine

Abstract

Abstract Parkinson's disease (PD) is a highly prevalent neurodegenerative disorder associated with abnormal brain iron metabolism. Ferroptosis is a newly discovered form of iron-dependent cell death. In recent years, many studies have identified ferroptosis as an important pathogenic mechanism of PD. Nevertheless, the underlying mechanisms remain unclear. A 6-hydroxydopamine (6-OHDA) stimulated the PD rat model and the PD cell model were used in this research. The experimental results showed that the level of kinesin 1 heavy chain (KIF5A) decreases, and the level of ferroptosis increases after 6-OHDA stimulation. A PD cell model is consistent with these results. The overexpression of KIF5A in SH-SY5Y cells significantly reduces intracellular lipid peroxidation, Fe2+ accumulation, and ferroptosis. In contrast, knockdown of KIF5A exacerbated lipid peroxidation and Fe2+ accumulation, and cellular ferroptosis was more severe. Therefore, this study provides new views and potential for studying treatment targets of PD by demonstrating that KIF5A protects cells from ferroptosis in a PD model.

Publisher

Research Square Platform LLC

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3