Ipsilateral restriction of chromosome movement along a centrosome, and apical-basal axis during the cell cycle-Reference-Cited by-同舟云学术

Ipsilateral restriction of chromosome movement along a centrosome, and apical-basal axis during the cell cycle

Published:2024-04-29 Issue: Volume: Page:
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Author:

Cai Pingping¹,Casas Christian Joseph²,Plancarte Gabriel Quintero²,Mikawa Takashi¹,Hua Lisa L²

Affiliation:

1. University of California, San Francisco

2. Sonoma State University

Abstract

Little is known about how distance between homologous chromosomes are controlled during the cell cycle. Here, we show that the distribution of centromere components display two discrete clusters placed to either side of the centrosome and apical/basal axis from prophase to G1 interphase. 4-Dimensional live cell imaging analysis of centromere and centrosome tracking reveals that centromeres oscillate largely within one cluster, but do not cross over to the other cluster. We propose a model of an axis-dependent ipsilateral restriction of chromosome oscillations throughout mitosis.

Publisher

Research Square Platform LLC

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