Assessment of the childhood neurodevelopmental status based on the diagnosis of congenital or acquired hypothyroidism

Abstract

Abstract Background Misdiagnosis and delay in the treatment of hypothyroidism, due to the role of thyroid hormone in the metabolism and neurodevelopment of children, can cause irreversible sequelae. This study was conducted to compare neurodevelopmental status of children with congenital or acquired hypothyroidism. Methods In a cohort study, neurodevelopmental status of two groups of 30 children with congenital or acquired hypothyroidism, was evaluated by the ages and stages questionnaire. Results There was no significant difference in childhood neurodevelopment, based on the diagnosis of congenital or acquired hypothyroidism. In congenital hypothyroidism, later diagnosis and lower thyroxine level were associated with neurodevelopmental disorders. Conclusion Neonatal diagnosis and early treatment of hypothyroidism can prevent late neurodevelopmental disorders.