Tumor Volume of Onset and MYCN Amplification Predict Poor Prognosis in Patients with Neuroblastoma

Abstract

Abstract Aim: To analysis the prognosis of neuroblastoma (NB) in children. Method: Clinical and pathological data of NB patients who were diagnosed and treated in Kunming Children's Hospital from January 2016 to December 2022 were retrospective analyzed. The prognostic factors and independent prognostic factors of NB were analyzed by Kaplan-Meier survival analysis and Cox risk ratio model. Result: According to the inclusion criteria and exclusion criteria, a total of 100 children were included in this study. The 1-year, 3-year and 5-year overall survival (OS) rates were 98.9%, 65.7% and 59.7%, respectively. The prognostic factors of OS were age, metastasis, stage of International Neuroblastoma Staging System (INSS), risk stratification, MYCN, ferritin (Fer), lactate dehydrogenase (LDH), neuron specific enolase (NSE), tumor volume of onset (TVO), image-defined risk factors (IDRFs), preoperative chemotherapy and recurrence. The independent prognostic factors were TVO and MYCN amplification. Conclusion: TVO and N-myc amplification and MYCN amplification are the independent prognostic factors have predictive value for NB OS prognosis. Patients with TVO ≥751.25 or MYCN amplification have poor prognosis.