Glubloc™ Reduces Postprandial Blood Glucose Surge in Healthy Individuals (A Placebo Controlled Pilot study).

Abstract

Abstract Background High glycaemic index (GI) foods can lead to negative health outcomes such as glucose spikes, insulin resistance, weight gain, and glucose crashes. Glubloc™ is a proprietary plant extract blend of Morus alba L and Malus domestica rind, enriched with polyphenolic flavonoids that inhibits enzymes responsible for carbohydrate digestion and glucose absorption and has shown potential in modulating blood sugar surge post-meal intake. Objective This study was aimed to investigate the impact of Glubloc™ on postprandial glucose response (PPGR) in healthy individuals after consuming a high GI meal (300g cooked rice) or a sucrose drink (70g table sugar dissolved in 400ml water). Design: Two studies were conducted using a placebo-controlled design. Subjects (n = 40 for rice meal study, n = 40 for sucrose drink study) received either placebo or Glubloc™ (500mg) before the meal/drink. Blood glucose levels were measured at various time points up to 180 minutes for the rice meal study and 120 minutes for the sucrose drink study. Results Glubloc™ supplementation significantly reduced PPGR in both the rice meal study and sucrose drink study. Compared to the placebo group, Glubloc™ resulted in significantly lower incremental area under the curve (iAUC) values for glucose levels (1063 mg/dL × min vs. 5090 mg/dL × min for rice meal; 859 mg/dL × min vs. 2266 mg/dL × min for sucrose drink). No adverse events were reported. Conclusions Glubloc™ supplementation effectively reduced postprandial glucose response in healthy individuals consuming high GI meals or sucrose drinks. It demonstrated potential as a safe and effective means to modulate blood glucose levels, thereby minimizing the negative effects of glucose and insulin spikes associated with high GI foods. Glubloc™ could be a valuable supplement for individuals seeking to manage their blood glucose levels after consuming carbohydrate-rich meals or sugary beverages. Further research is warranted to explore its broader applications in managing metabolic conditions.