Abstract
Background/Objectives: There is a lack of certainty in dietary prescription for individuals with inflammatory bowel disease (IBD) due to heterogeneity in studies to date. The aim of this study was to investigate the efficacy on disease activity of a modified anti-inflammatory dietary pattern purposely designed to reduce intake of food additives (IBD-MAID), compared to standard care, in adults with IBD.
Subject/Methods: Adults with IBD were randomised to IBD-MAID (meals provided) [n=29] or general healthy eating (GHE) [n=29] for 8 weeks. Disease activity, faecal calprotectin (FC), C-reactive protein (CRP), symptoms and quality of life (S&QOL) were assessed using validated tools.
Results:The IBD-MAID was well tolerated and adhered to (92% adherence). At week 8, there was no statistically significant difference in change from baseline in outcome measures between groups. However, baseline to week 8 analysis indicated: 1) statistically significant improvements in S (p = 0.001) & QOL (p = 0.004), FC (p = 0.007) and Crohn’s disease activity ( p = 0.03) but not ulcerative colitis, in individuals following the IBD-MAID and 2) statistically significant improvement in QOL in individuals receiving GHE (p = 0.015). Correlation analysis revealed a r decrease in food additives intake was associated with statistically significant improvements in FC, S & QOL and alignment of anti-inflammatory dietary principles with improvements in QOL.
Conclusion: The IBD-MAID was well tolerated. The most novel finding pertains to the correlation between reducedfood additives intake and improvements in inflammatory markers, S&QOL. Further research is needed to explore the effects of food additives exposure on IBD course.
ANZCTR: 12619001500145