Affiliation:
1. Tabriz University of Medical Sciences
Abstract
Abstract
In the present study, the solubility values of amlodipine besylate (AMB) in the binary mixtures of polyethylene glycol 400 and ethanol were determined using the shake-flask method at 293.2 to 313.2 K under atmospheric pressure (≈ 85 kPa) and correlated to some cosolvency and activity coefficient models. The accuracy of each model was marked by the mean relative deviations (MRD%) of the back-calculated solubility data. Also, the apparent thermodynamic properties of AMB dissolution were computed by the van't Hoff and Gibbs equations.
Publisher
Research Square Platform LLC