Differential silica nanoparticles functionalized with branched poly(1-Vinyl-1,2,4-triazole): antibacterial, antifungal, and cytotoxic qualities

Abstract

Abstract This research aims to improve antimicrobial materials based on functional silica nanoparticles. Three different methods were used in the study to create silica nanoparticles with other properties. The nanoparticles' morphological structures are porous, hollow, and filled with spherical forms. The surface of these nanoparticles was grafted with poly(1-vinyl-1,2,4-triazole) (PVTri). The morphological properties of nanocomposites were used for analyze. In contrast, thermal gravimetric analysis was used to characterize the thermal properties of nanocomposites (TGA). The silica nanoparticles were evaluated for them in vitro antimicrobial activity against, Escherichia coli, Staphylococcus aureus, Saccharomyces cerevisiae using minimum inhibitory concentration (MIC) measurement. Silica nanoparticles have different antifungal and antibacterial properties related to their structure. The cytotoxic effects of the silica nanoparticles on HaCaT cells were performed with an MTS assay. In this study, we observed that high doses of HSS and e-SiO2 decreased cell growth, while HSS and e-SiO2 composite with PVTri increased cell proliferation.