Association between survivin gene Polymorphism -31G/C and Risk of Lung and Gastrointestinal cancers : A Systematic Review and Meta-Analysis

Abstract

Abstract Survivin (BIRC5) is an anti-apoptosis protein overexpressed in most of the cancers and associated with poor clinical outcome. We haveprovided an updated meta-analysis of -31G/C (rs9904341) gene polymorphism which is highly associated with cancer risk. Methodology: A comprehensive literature search in PubMed and Google scholar database was conducted. A total of 10472 cases and 12193 controls from 51 studies were included in this meta-analysis. This study was prospectively registered in PROSPERO andsensitivity analysis, risk of bias analysis and statistical analysis were performed, and pooled odds ratio (ORs) with 95% confidence interval (CIs) was calculated to assess the strength of association. All analyzed were achieved using RevMan 5.4 software and Excel 2013 version. Results: The overall meta-analysis indicates that survivin gene polymorphism − 31G/C is highly associated with overall cancer risk in allelic (C vs G, OR = 1.25,95% CI = 1.15 to 1.37, P < 0.00001), homozygous co-dominant (CC vs GG, OR = 1.53, 95% CI = 1.23 to 1.90, P = 0.0001), heterozygous co-dominant (CC vs CG, OR = 1.34, 95% CI = 1.18 to 1.52, P < 0.00001), dominant model(CC + CG vs GG, OR = 1.29, 95% CI = 1.14 to 1.46, P = < 0.0001) and recessive model (CG + GG vs CC, OR = 0.70, 95% CI = 0.61 to 0.81, P < 0.00001). Stratified analysis revealed that the variant significantly increase the risk in Asian population. For which cancers was the SNP conferring risk, protection and no change , Conclusion:-31G/C polymorphism of BIRC5 gene is associated with the risk of cancer in the Asian population. However, further large scale clinical studies are required to re-evaluate this result in future.