Survivin at a glance-Reference-Cited by-同舟云学术

Survivin at a glance

Published:2019-04-01 Issue:7 Volume:132 Page:
ISSN:1477-9137
Container-title:Journal of Cell Science
language:en
Short-container-title:

Author:

Wheatley Sally P.¹^ORCID,Altieri Dario C.²

Affiliation:

1. Department of Biochemistry, School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK

2. The Wistar Institute Cancer Center, Philadelphia, PA 19104, USA

Abstract

ABSTRACT Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is only expressed in actively proliferating cells, but is upregulated in most, if not all cancers; consequently, it has received significant attention as a potential oncotherapeutic target. In this Cell Science at a Glance article and accompanying poster, we summarise our knowledge of survivin 21 years on from its initial discovery. We describe the structure, expression and function of survivin, highlight its interactome and conclude by describing anti-survivin strategies being trialled.

Funder

National Institutes of Health

Publisher

The Company of Biologists

Subject

Cell Biology

Link

http://journals.biologists.com/jcs/article-pdf/doi/10.1242/jcs.223826/1964771/jcs223826.pdf

Reference104 articles.

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2. Analysis of the functional repertoire of a mutant form of survivin, K129E, which has been linked to lung cancer;Aljaberi;Cancer Cell Int.,2014

3. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma;Ambrosini;Nat. Med.,1997