Association of Selenium Levels with Neurodegenerative disease: A Systemic Review and Meta-analysis

Abstract

Abstract Background Neurodegenerative diseases are debilitating and incurable disorders with a rapid-rising prevalence. Selenium, a trace element, works in anti-oxidant and anti-inflammatory aspects through selenoprotein biologically. Nowadays, it is in a great urgency to discover the intrinsic relationship between selenium and neurodegenerative diseases, and find more effective therapeutic strategies to combat these devastating diseases. Method Five public databases including PubMed, Web of Science, EMBASE, Cochrane, Clinical Trials were searched in our research. Random model effects were chosen, and Higgins inconsistency analyses (I2), Cochrane’s Q test, Tau2 were calculated to evaluate the heterogeneity. Result The association of selenium in neurodegenerative diseases patients including Alzheimer’s disease, Parkinson’s disease, Multiple sclerosis, Amyotrophic lateral sclerosis and Huntington’s disease was studied. The strong relation was only found in AD patients, especially the erythrocytes in sub-group analysis of various tested tissue type. Conclusion Generally, this meta-analysis indicated that Alzheimer’s disease is strongly associated with lower selenium concentration, which may provide clinical reference in the future. However, more researches are in urgent need for further study and treatment for neurodegenerative diseases.