Affiliation:
1. Department of Chemistry, University of Mysore, Manasagangotri, Mysore, Karnataka, India
Abstract
Two simple and rapid titrimetric methods are described for the determination
of bupropion hydrochloride (BUPH) in pharmaceuticals. The proposed methods
are based on the solvent extraction-titration of BUPH with two
ion-association reagents, i.e. sodium lauryl sulphate (SLS) and
tetraphenylborate (TPB). In method A, SLS was used as titrant and the
titration was carried out in the presence of dilute sulphuric acid and
chloroform using dimethyl yellow as indicator whereas in method B, the
titrant was TPB and the titration was done in borate-phosphate buffer of pH
6.0 and 1,2-dichloroethane with tetrabromophenolphthalein ethyl ester (TBPE)
as indicator. In the two-phase titrations, the proposed procedures give sharp
end points as the color of the organic phase changes from yellow to pink in
method A and from red-violet to yellow in method B. The methods are
applicable over the ranges of 1.0-20.0 and 3.0-10.0 mg of BUPH for method A
and method B, respectively. The accuracy and precision of the methods are
good. The methods were applied successfully to the determination of BUPH in
tablets and the results were in agreement with the label claim and those of
the comparison method.
Publisher
National Library of Serbia
Subject
General Chemical Engineering
Cited by
5 articles.
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