Kinetic study and peak purity determination of bupropion hydrochloride using RRLC/DAD and HPLC/MWD methods: stability study and application in pharmaceutical preparation and in synthetic mixtures with nicotine

Author:

El-Kosasy Amira M.12345,Hussein Lobna A.12345,Salama Nahla N.1675,Sedki Nehal G.1675

Affiliation:

1. Analytical Pharmaceutical Chemistry Department

2. Faculty of Pharmacy

3. Ain Shams University

4. Cairo

5. Egypt

6. National Organization for Drug Control and Research NODCAR

7. Giza

Abstract

Two validated stability indicating chromatographic methods have been developed and used for the kinetic study and determination of bupropion HCl in presence of its degradation products and nicotine.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference36 articles.

1. S. C. Sweetman and P. S.Blake, Martindale – the complete drug reference, The Pharmaceutical Press, London, 36th edn, 2009

2. The aqueous stability of bupropion

3. M. A. Clark , R.Finkel, J. A.Rey, K.Whalen and R. A.Harvey, Lippincott’s illustrated reviews: pharmacology, Lippincott’s Williams & Wilkins, USA, 5th edn, 2012

4. How does bupropion work as a smoking cessation aid?

5. United States (US) pharmacopeia, 34th edn and the National Formulary (NF), 29th edn, USA, U.S. Pharmacopeial Convention, Rockville, MD, 2014

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