Affiliation:
1. Tehnološki fakultet, Leskovac
2. Farmaceutska i hemijska industrija, Zdravlje-Actavis, Leskovac
Abstract
A sensitive and selective RP-HPLC method was developed and validated for the quantitative determination of trimazolin hydrochloride in nasal drops formulations. The mobile phase composition was water-acetonitrile (50:50, v/v) and the UV detection was carried out at 270 nm. Linearity range in the concentration range of 10 to 110 ?g cm-3. The method was tested and validated for various parameters according to ICH guidelines. The detection and quantization limits were found to be 1.45 and 4.8 ?g cm-3, respectively. The results demonstrated that the procedure for estimation of trimazolin hydrochloride in nasal drops formulations was accurate, precise and reproducible.
Publisher
National Library of Serbia
Subject
General Chemical Engineering,General Chemistry
Cited by
2 articles.
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