Preparation of 2-heteroatom substituted 4-oxo-4-arylbutanoates via thio- and aza-Michael addition

Author:

Liu Huili1,Lv Xin1,Zhou Liejin1,Yin Ruifeng1,Wang Xiaoxia1

Affiliation:

1. Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces, College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua, P. R. China

Abstract

Efficient regioselective conjugate additions of thiophenols and benzotriazole to 4-aryl-4-oxobut-2-enoates have been achieved under mild conditions. Thus a variety of 2-arylthio-4-oxo-4-arylbutanoates and 2- benzotriazolyl-4-oxo-4-arylbutanoates were conveniently synthesized in good to excellent yields.

Publisher

National Library of Serbia

Subject

General Chemistry

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