Apoptosis of human fetal pancreatic islets during short-term culture-Reference-Cited by-同舟云学术

Apoptosis of human fetal pancreatic islets during short-term culture

Published:2009 Issue:1 Volume:61 Page:9-15
ISSN:0354-4664
Container-title:Archives of Biological Sciences
language:en
Short-container-title:ARCH BIOL SCI BELGRA

Author:

Djordjevic P.B.¹,Dimitrijevic-Sreckovic Vesna¹,Bumbasirevic V.¹,Colovic R.¹,Nikolic D.¹,Raketic Nevenka¹,Canovic F.¹

Affiliation:

1. Institut za endokrinologiju, dijabetes i bolesti metabolizma, Klinički centar Srbije, Beograd

Abstract

We investigated the influence of short-term culture in vitro on the appearance of apoptosis of human fetal pancreatic islets (HFIs) and its effect on the mass and insulin-secretory capacity (ISC) of ?-cells. It was found that apoptosis was present from the end of the culture period, increasing as a function of time and leading to decrease of ?-cell mass. At the same time, ISC decreased. The decrease of ?-cell mass and ISC may influence significantly the clinical outcome of HFIs transplantation in type 1 diabetic patients.

Publisher

National Library of Serbia

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology

Reference25 articles.

1. Identification of Insulin‐Producing Cells Derived from Embryonic Stem Cells by Zinc‐Chelating Dithizone

2. Edmonton's islet success tough to duplicate elsewhere

3. β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

4. Cytoprotection of pancreatic islets before and early after transplantation using gene therapy

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