AN INVESTIGATION OF THE ACE INHIBITORY ACTIVITY, ANTIOXIDANT CAPACITY, AND PHYTOCHEMICAL CONSTITUENTS OF POLAR AND NON-POLAR EXTRACTS OF ZIZIPHUS JUJUBA FRUIT: STATISTICAL SCREENING THE MAIN COMPONENTS RESPONSIBLE FOR BIOACTIVITY-Reference-Cited by-同舟云学术

AN INVESTIGATION OF THE ACE INHIBITORY ACTIVITY, ANTIOXIDANT CAPACITY, AND PHYTOCHEMICAL CONSTITUENTS OF POLAR AND NON-POLAR EXTRACTS OF ZIZIPHUS JUJUBA FRUIT: STATISTICAL SCREENING THE MAIN COMPONENTS RESPONSIBLE FOR BIOACTIVITY

Published:2024-06-15 Issue:3 Volume:49 Page:554-566
ISSN:1300-3070
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Author:

Fındık Bahar¹^ORCID,Yıldız Hilal²^ORCID,Birişçi Esma³^ORCID,Yiğitkan Serkan⁴^ORCID,Köseoğlu Yılmaz Pelin⁵^ORCID,Ertaş Abdulselam⁴^ORCID

Affiliation:

1. NEVSEHIR HACI BEKTAS VELI UNIVERSITY, FACULTY OF ARTS AND SCIENCES

2. NEVSEHIR HACI BEKTAS VELI UNIVERSITY, FACULTY OF ENGINEERING-ARCHITECTURE

3. BURSA ULUDAG UNIVERSITY, FACULTY OF ECONOMICS AND ADMINISTRATIVE SCIENCES

4. DICLE UNIVERSITY, FACULTY OF PHARMACY

5. ISTANBUL UNIVERSITY, FACULTY OF PHARMACY

Abstract

Herein, the angiotensin I-converting enzyme (ACE) inhibitory activity, antioxidant capacity, total polyphenol contents (TPC), and phytochemical profiles of polar and non-polar extracts of dried Ziziphus jujuba fruits were investigated, along with the statistical determination of the main components responsible for ACE inhibitory activity. The non-polar extract expressed the strongest ACE inhibitory activity (99.81%) among the extracts. The non-polar extract also exhibited the highest DPPH scavenging activity (IC50 of 30.63), linoleic acid/β-carotene bleaching capacity (89.31%), and TPC (59.47 mg GAE/g). The phenolic profiles of the extracts were identified by LC-MS/MS, and the presence of seven triterpenoid species in the extracts was examined using GC-MS techniques. The principal constituents included 19 phenolics, 2 organic acids, and 4 triterpenoids. A Pearson correlation and principal component analysis were conducted to find the correlation between individual phenolic compounds and ACE inhibitory activity.

Publisher

Association of Food Technology, Turkey

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