Synthesis, characterization, structural features and cytotoxicity of innovative zinc(II) complex derived from ONS-donor thio-Schiff base of acyl pyrazolone-Reference-Cited by-同舟云学术

Synthesis, characterization, structural features and cytotoxicity of innovative zinc(II) complex derived from ONS-donor thio-Schiff base of acyl pyrazolone

Published:2019-06-30 Issue:2 Volume:10 Page:131-138
ISSN:2153-2257
Container-title:European Journal of Chemistry
language:en
Short-container-title:Eur J Chem

Author:

Shaikh Irfan¹^ORCID,Vohra Aliasgar²^ORCID,Devkar Ranjitsinh²^ORCID,Jadeja Rajendrasinh¹^ORCID

Affiliation:

1. Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara-390002, India

2. Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara 390 002, India

Abstract

Novel acyl pyrazolone and thio-Schiff base of acyl pyrazolone ligand HL (2-((4-chlorophenyl)(1-(3-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)methylene) hydrazine-1-carbothioamide) has been synthesised and characterized by FT-IR and 1H NMR techniques. This unusual coordinated complex [Zn(L)(CH3C00)(H2O)]CH3CH2OH has been synthesized and characterized by FT-IR, thermogravimetric analysis (TGA), UV-Vis spectroscopy and single crystal X-ray diffraction. 1H NMR confirms the structure of the thio-Schiff base used in the study. The structural data reveal that mononuclear Zn(II)complex has distorted square pyramidal geometry. S-S interaction, Inter molecular and intra molecular H-Bond found in crystal packing of the complex. The complex has been screened for MTT assay against A549 cell lines. The Zn(II) complex is cytotoxic against the screened cell line at low concentration.

Publisher

European Journal of Chemistry

Link

http://www.eurjchem.com/index.php/eurjchem/article/viewFile/1858/pdf_1858

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